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Beclin 1, Autophagy Related (BECN1) antibody
|Synonyms||ATG6, VPS30, beclin1, MGC6843, 4921513J16Rik, 5430417M23Rik, MGC73097, zgc:73097, BECN1, becn1, MGC80672, MGC126978, atg6, vps30, Beclin-1, DKFZp459C0719|
Human, Rat (Rattus), Mouse (Murine)
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|6 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30)|
|Immunogen||A synthetic peptide from huamn coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in rat and mouse.|
|Description||Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role inautophagy. SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note: Expressed in dendrites and cell bodies of cerebellar Purkinje cells TISSUE SPECIFICITY: Ubiquitous Also known as: Beclin-1, BECN1, GT197, ATG6, VPS30, beclin1.|
|Specificity||Appears to be specific for Beclin-1.|
|Application Notes||IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Rommens, Durocher, McArthur et al.: "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21." in: Genomics, Vol. 28, Issue 3, pp. 530-42, 1996 (PubMed).
Aita, Liang, Murty et al.: "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21." in: Genomics, Vol. 59, Issue 1, pp. 59-65, 1999 (PubMed).
Liang, Jackson, Seaman et al.: "Induction of autophagy and inhibition of tumorigenesis by beclin 1." in: Nature, Vol. 402, Issue 6762, pp. 672-6, 2000 (PubMed).
Kihara, Kabeya, Ohsumi et al.: "Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network." in: EMBO reports, Vol. 2, Issue 4, pp. 330-5, 2001 (PubMed).
Koneri, Goi, Hirono et al.: "Beclin 1 gene inhibits tumor growth in colon cancer cell lines." in: Anticancer research, Vol. 27, Issue 3B, pp. 1453-7, 2007 (PubMed).
Lee, Jeong, Yoo et al.: "Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 115, Issue 12, pp. 1357-63, 2008 (PubMed).