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ATG4C antibody (ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae))

Details for Product anti-ATG4C Antibody No. ABIN349989, Supplier: Log in to see
Antigen
  • Apg4-C
  • APG4-C
  • apg4c
  • Apg4c
  • APG4C
  • atg4cl
  • Atg4cl
  • AUTL1
  • Autl1
  • AUTL3
  • wu:fc56g07
  • zgc:86888
Reactivity
Human, Mouse (Murine), Rat (Rattus)
102
48
43
1
1
1
Host
Sheep
85
18
9
3
Clonality
Polyclonal
Conjugate
This ATG4C antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
94
37
29
15
11
11
4
1
1
1
Supplier
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Immunogen A synthetic peptide from human cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3) conjugated to an immunogenic carrier protein has been used as the antigen.
Isotype IgG
Specificity Specific for ATG4C.
Alternative Name ATG4C (ATG4C Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required forautophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Enzyme regulation: Inhibited by N-ethylmaleimide.
Tissue specificity: Highly expressed in skeletal muscle, heart, liver and testis. Also known as: ATG4C, autophagin-3, APG4C, AUTL1, AUTL3, APG4-C, FLJ14867, ATG4autophagy related 4 homolog C (S. cerevisiae),autophagy-related protein 4 homolog C,autophagy-related cysteine endopeptidase 3, AUT-like 3 cysteine endopeptidase.
Research Area Cancer, Autophagy, Proteolysis / Ubiquitin
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Mariño, Uría, Puente, Quesada, Bordallo, López-Otín: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).