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Details for Product No. ABIN349990

ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C) antibody

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Antigen
Synonyms APG4-C, APG4C, AUTL1, AUTL3, Apg4-C, Apg4c, Atg4cl, Autl1, apg4c, atg4cl, zgc:86888, wu:fc56g07
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN349990
Quantity 150 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, rat, mouse cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3) conjugated to immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for ATG4C.
Purity whole serum
Alternative Name cysteine protease ATG4C (autophagin-3, APG4C)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. Cysteine protease required forautophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Enzyme regulation: Inhibited by N-ethylmaleimide.
Tissue specificity: Highly expressed in skeletal muscle, heart, liver and testis. Also known as: ATG4C, autophagin-3, APG4C, AUTL1, AUTL3, APG4-C, ATG4autophagy related 4 homolog C (S. cerevisiae),autophagy-related protein 4 homolog C,autophagy-related cysteine endopeptidase 3, AUT-like 3 cysteine endopeptidase.
UniProt Q96DT6
Research Area Autophagy
Application Notes IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Alternatives for antigen "ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C)", type "Antibodies"
Hosts (86), (5), (4), (1)
Reactivities (82), (72), (66), (48), (48), (48)
Applications (50), (44), (30), (18), (14), (10), (5), (3), (2), (1), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (12), (12), (12), (12), (3), (2), (2), (2), (2), (1), (1)
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