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Details for Product No. ABIN349991

GABA(A) Receptor-Associated Protein (GABARAP) antibody

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Antigen
Synonyms ATG8A, GABARAP-a, MM46, GABARAP
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN349991
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human GABA(A) receptor-associated protein (GABARAP, MM46, FLC3B) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for LAT1.
Purity IgG
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. GABARAP belongs ot a large family of proteins that mediate intracellular membrane trafficking and/or fusion. GABARAP binds not only to GABA, type A but also to tubulin, gephrin, and ULK1. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. It interacts with GPHN and NSF, interacts with GABRG2, beta-tubulin and ULK1.
Subcellular location: Intracytoplasmic membrane. Cytoplasm, cytoskeleton. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Also known as: GABA(A) receptor-associated protein, MM46, GABARAP.
UniProt Q9Z127
Research Area Signaling, Metabolism
Application Notes Use at a concentration of 10-50 µg/mL.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Paz, Elazar, Fass: "Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25445-50, 2000 (PubMed).

Kneussel, Haverkamp, Fuhrmann et al.: "The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8594-9, 2000 (PubMed).

Tanida, Komatsu, Ueno et al.: "GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3." in: Biochemical and biophysical research communications, Vol. 300, Issue 3, pp. 637-44, 2002 (PubMed).

Sou, Tanida, Komatsu et al.: "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3017-24, 2006 (PubMed).

Boileau, Pearce, Czajkowski: "Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 49, pp. 11219-30, 2005 (PubMed).

Luo, Kranzler, Zuo et al.: "CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness." in: Human molecular genetics, Vol. 16, Issue 13, pp. 1557-68, 2007 (PubMed).

Alternatives for antigen "GABA(A) Receptor-Associated Protein (GABARAP)", type "Antibodies"
Hosts (52), (7), (4)
Reactivities (58), (25), (23), (13), (13), (1), (1)
Applications (54), (21), (10), (8), (7), (6), (2), (1), (1)
Conjugates (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (2), (2), (2), (2), (1), (1), (1)
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