GABARAP antibody

Catalog No. ABIN349991

Product Details anti-GABARAP Antibody

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Reactivity: Human, Mouse, Rat

Host: Sheep

Clonality: Polyclonal

Conjugate: This GABARAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for GABARAP.

Immunogen: A synthetic peptide from human GABA(A) receptor-associated protein (GABARAP, MM46, FLC3B) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.

Isotype: IgG

Application Details

Application Notes: Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for GABARAP

Target: GABARAP (GABA(A) Receptor-Associated Protein (GABARAP))

Alternative Name: GABARAP (GABARAP Products)

Synonyms: GABARAP antibody, ATG8A antibody, GABARAP-a antibody, MM46 antibody, gabarap antibody, mg:bb02b03 antibody, GABA type A receptor-associated protein antibody, gamma-aminobutyric acid receptor-associated protein antibody, GABA(A) receptor-associated protein a antibody, gamma-aminobutyric acid receptor associated protein antibody, GABARAP antibody, LOC5568843 antibody, Gabarap antibody, gabarapa antibody

Background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. GABARAP belongs ot a large family of proteins that mediate intracellular membrane trafficking and/or fusion. GABARAP binds not only to GABA, type A but also to tubulin, gephrin, and ULK1. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. It interacts with GPHN and NSF, interacts with GABRG2, beta-tubulin and ULK1.
Subcellular location: Intracytoplasmic membrane. Cytoplasm, cytoskeleton. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules.
Tissue specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Also known as: GABA(A) receptor-associated protein, MM46, GABARAP.

Pathways: Autophagy