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GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2) antibody

Details for Product No. ABIN349994, Supplier: Login to see
Antigen
  • GABARAPL2
  • atg8
  • gef2
  • gate16
  • gate-16
  • Gef2
  • ATG8
  • ATG8C
  • GATE-16
  • GATE16
  • GEF-2
  • GEF2
  • zgc:92319
  • 0610012F20Rik
  • 2900019O08Rik
  • AI173605
Reactivity
Human, Mouse (Murine), Rat (Rattus)
163
31
30
2
1
1
1
1
1
Host
Rabbit
158
4
3
1
Clonality
Polyclonal
Conjugate
Un-conjugated
21
21
21
10
10
10
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
115
98
79
16
11
7
6
1
1
Supplier
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Immunogen A synthetic peptide from human GABA(A) receptor-associated protein-like 2 (GABARAPL2, ATG8) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for GABARAPL2.
Purification Whole serum
Alternative Name GABARAPL2 (GABARAPL2 Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association withGOSR1.
Subcellular location: Golgi apparatus.
Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Also known as: FLC3A, GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, General protein transport factor p16, MAP1 light chain 3-related protein.
Research Area Cancer
Pathways
Application Notes Use at a dilution of 1 : 300 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Mehrle, Rosenfelder, Schupp et al.: "The LIFEdb database in 2006." in: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, 2005 (PubMed).

Sou, Tanida, Komatsu et al.: "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3017-24, 2006 (PubMed).

Wiemann, Arlt, Huber et al.: "From ORFeome to biology: a functional genomics pipeline." in: Genome research, Vol. 14, Issue 10B, pp. 2136-44, 2004 (PubMed).

Scherz-Shouval, Sagiv, Shorer et al.: "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14053-8, 2003 (PubMed).

Tanida, Tanida-Miyake, Nishitani et al.: "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 256-62, 2002 (PubMed).

Okazaki, Yan, Yuasa et al.: "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation." in: Brain research. Molecular brain research, Vol. 85, Issue 1-2, pp. 1-12, 2001 (PubMed).