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Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (4th cytoplasmic loop) antibody

Antigen

Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2)
Epitope
Alternatives

4th cytoplasmic loop
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Mouse (Murine)
Application
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
2 references available
Catalog no. ABIN350003
Quantity 100 µl  (Variants)
Price 413.33 $   Plus shipping costs $35.00
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Additional Information
Application Details Publications Alternatives Secondary Antibodies Variants back to top

Alternative name polycystic kidney disease 2 protein homolog (PKD2, Polycystin-2, PC2,TRPP2) (4th cytoplasmic loop)
Swiss-Prot O35245
Immunogen A synthetic peptide from the 4th cytoplasmic loop of mouse, rat Polycystic kidney disease 2 protein homolog (PKD2, Polycystin-2, PC2, TRPP2) conjugated to an immunogenic carrier protein was used as the immunogen.
Format Lyophilized
Description FUNCTION: Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. SUBUNIT: Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in mesenchymally derived structures in the developing embryo at day 12.5. In adult, mostly expressed in kidney. Also known as: PKD2, Polycystin-2, PC2, TRPP2.
Specificity Appears to be specific for PKD2.

Application Details
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Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Purity whole serum
Storage Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Restrictions For Research Use only

Publications
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Publications Wu, Mochizuki, Le et al.: "Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2." in: Genomics, Vol. 45, Issue 1, pp. 220-3, 1997 (PubMed).

Pennekamp, Bogdanova, Wilda et al.: "Characterization of the murine polycystic kidney disease (Pkd2) gene." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 9, Issue 9, pp. 749-52, 1999 (PubMed).

Alternatives
Application Details Publications Secondary Antibodies Variants back to top

Alternatives for antigen "Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2)", type "Antibodies"
Hosts Rabbit (21), Goat (1)
Reactivities Human (22), Mouse (Murine) (20), Rat (Rattus) (19), Chicken (17), Cow (Bovine) (16), Dog (Canine) (16), Pig (Porcine) (1), Rabbit (1)
Applications Flow Cytometry (FACS) (18), Immunofluorescence (IF) (18), Western Blotting (WB) (5), ELISA (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
Conjugates Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes 4th cytoplasmic loop (1)