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Details for Product No. ABIN350005

RSSA (RPSA) Alternative 1 (Precursor) antibody

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Antigen
Epitope
Precursor
Reactivity
Human, Mouse (Murine), Rat (Rattus)
Host
Rabbit
Clonality Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN350005
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, mouse and rat RSSA conjugated to immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for RSSA precursor expressed on globose basal cells (GBCs).
Purity whole serum
Background The expression of nonintegrin laminin receptor precursor protein onolfactory stem and progenitor cells has been reported by Schwob J, et al. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Also known as: Immature laminin receptor, nonintegrin laminin receptor precursor, 40S ribosomal protein SA, p40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance-associated protein MGr1-Ag, LAMBR, LAMR1, RPSA ribosomal protein SA, LRP, 67LR, 37LRP.
UniProt P08865
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Satoh, Narumi, Sakai et al.: "Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung." in: Cancer letters, Vol. 62, Issue 3, pp. 199-203, 1992 (PubMed).

Van den Ouweland, Van Duijnhoven, Deichmann et al.: "Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes." in: Nucleic acids research, Vol. 17, Issue 10, pp. 3829-43, 1989 (PubMed).

Yow, Wong, Chen et al.: "Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 17, pp. 6394-8, 1988 (PubMed).

Jackers, Minoletti, Belotti et al.: "Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3." in: Oncogene, Vol. 13, Issue 3, pp. 495-503, 1996 (PubMed).

Kenmochi, Kawaguchi, Rozen et al.: "A map of 75 human ribosomal protein genes." in: Genome research, Vol. 8, Issue 5, pp. 509-23, 1998 (PubMed).

Jang, Kim, Schwob: "Nonintegrin laminin receptor precursor protein is expressed on olfactory stem and progenitor cells." in: The Journal of comparative neurology, Vol. 502, Issue 3, pp. 367-81, 2007 (PubMed).

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