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Unc-51 Like Kinase 1 (C. Elegans) (ULK1) (AA 350-410) antibody

Details for Product No. ABIN350008, Supplier: Log in to see
Antigen
  • ULK1
  • si:dkey-11o18.7
  • ulk1
  • ATG1
  • ATG1A
  • UNC51
  • Unc51.1
  • hATG1
  • AU041434
  • mKIAA0722
Epitope
AA 350-410
52
43
35
21
21
20
17
15
15
14
13
13
6
5
3
3
2
2
2
2
2
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
224
36
32
6
3
2
1
1
1
1
1
1
Host
Sheep
216
6
2
Clonality
Polyclonal
Conjugate
Un-conjugated
21
20
20
18
18
18
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
138
119
75
22
15
13
10
5
2
2
1
1
Supplier
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Immunogen A synthetic peptide from aa region 350-410 of human ULK1 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in rat and mouse.
Isotype IgG
Specificity Specific for ULK1.
Alternative Name ULK1 (ULK1 Antibody Abstract)
Background Function: Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subunit: Interacts with GABARAP and GABARAPL2. Also known as: Unc-51-like kinase 1, ATG1, UNC51, Unc51.1.
Research Area Cardiovascular, Autophagy
Pathways
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Chan, Kir, Tooze: "siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy." in: The Journal of biological chemistry, Vol. 282, Issue 35, pp. 25464-74, 2007 (PubMed).

Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Young, Chan, Hu et al.: "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes." in: Journal of cell science, Vol. 119, Issue Pt 18, pp. 3888-900, 2006 (PubMed).

Tomoda, Kim, Zhan et al.: "Role of Unc51.1 and its binding partners in CNS axon outgrowth." in: Genes & development, Vol. 18, Issue 5, pp. 541-58, 2004 (PubMed).

Okazaki, Yan, Yuasa et al.: "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation." in: Brain research. Molecular brain research, Vol. 85, Issue 1-2, pp. 1-12, 2001 (PubMed).

Kuroyanagi, Yan, Seki et al.: "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment." in: Genomics, Vol. 51, Issue 1, pp. 76-85, 1998 (PubMed).