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Taste Receptor, Type 1, Member 3 (TAS1R3) (1st Extracellular Loop) antibody

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Synonyms tas1r3, T1R3, Sac, T1r3
1st Extracellular Loop
(27), (27), (14), (6), (6), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine)
(92), (18), (16), (1)
(64), (38)
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (50), (12), (11), (10), (8), (1)
Pubmed 10 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 1t extracellular loop of mouse TAS1R3 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous with the corresponding sequence in rat.
Specificity Specific for TAS1R3.
Purification Whole serum
Alternative Name TAS1R3 (TAS1R3 Antibody Abstract)
Background Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Subunit: Forms homodimers or heterodimers with TAS1R1 and TAS1R2.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in circumvallate, foliate and fungiform taste papillae as well as in taste buds on the palate. Also expressed in testis. Not expressed in brain, heart, kidney, liver or spleen. The topographic distribution in various taste papillae is different from those of other T1R members. Also known as: Taste receptor type 1 member 3 (precursor), sweet taste receptor T1R3, saccharin preference protein, Sac, T1r3, Tr3, Tas1r3, TS1R3.
Research Area Signaling, Receptors
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Reed, Li, Li et al.: "Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 4, pp. 938-46, 2004 (PubMed).

Zhao, Zhang, Hoon et al.: "The receptors for mammalian sweet and umami taste." in: Cell, Vol. 115, Issue 3, pp. 255-66, 2003 (PubMed).

Ariyasu, Matsumoto, Kyono et al.: "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose." in: In vitro cellular & developmental biology. Animal, Vol. 39, Issue 1-2, pp. 80-8, 2003 (PubMed).

Nelson, Chandrashekar, Hoon et al.: "An amino-acid taste receptor." in: Nature, Vol. 416, Issue 6877, pp. 199-202, 2002 (PubMed).

Li, Bachmanov, Li et al.: "Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 13, Issue 1, pp. 5-19, 2002 (PubMed).

Bachmanov, Li, Reed et al.: "Positional cloning of the mouse saccharin preference (Sac) locus." in: Chemical senses, Vol. 26, Issue 7, pp. 925-33, 2001 (PubMed).

Nelson, Hoon, Chandrashekar et al.: "Mammalian sweet taste receptors." in: Cell, Vol. 106, Issue 3, pp. 381-90, 2001 (PubMed).

Sainz, Korley, Battey et al.: "Identification of a novel member of the T1R family of putative taste receptors." in: Journal of neurochemistry, Vol. 77, Issue 3, pp. 896-903, 2001 (PubMed).

Max, Shanker, Huang et al.: "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac." in: Nature genetics, Vol. 28, Issue 1, pp. 58-63, 2001 (PubMed).

Kitagawa, Kusakabe, Miura et al.: "Molecular genetic identification of a candidate receptor gene for sweet taste." in: Biochemical and biophysical research communications, Vol. 283, Issue 1, pp. 236-42, 2001 (PubMed).

Catalog No. ABIN350012
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