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Taste Receptor, Type 2, Member 7 (TAS2R7) (2nd Extracellular Domain) antibody

Details for Product No. ABIN350013, Supplier: Log in to see
Antigen
  • t2r1
  • t2r7
  • trb4
  • T2R7
  • Tas2r13
  • Tas2r7
  • STC74
  • T2R30
  • Tas2r30
  • mt2r42
  • TRB4
  • Patr-T2R7
Epitope
2nd Extracellular Domain
18
16
3
2
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
45
1
1
Host
Rabbit
46
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
33
22
12
6
3
2
1
Supplier
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Immunogen A synthetic peptide from 2d extracellular domain of mouse taste receptor, type 2, member 7 (Tas2r7, T2R7) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat.
Specificity Specific for TAS2R7.
Purification Whole serum
Alternative Name TAS2R7 (TAS2R7 Antibody Abstract)
Background Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues. Also known as: Taste receptor type 2 member 7, T2R7, T2R6, T2R30, STC7-4, mT2R42, Tas2r130, Tas2r6, Tas2r7.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Scalzo, Wheat, Dubbelde et al.: "Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus." in: Immunogenetics, Vol. 55, Issue 6, pp. 370-8, 2003 (PubMed).

Shi, Zhang, Yang et al.: "Adaptive diversification of bitter taste receptor genes in Mammalian evolution." in: Molecular biology and evolution, Vol. 20, Issue 5, pp. 805-14, 2003 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Wu, Rozengurt, Yang et al.: "Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 4, pp. 2392-7, 2002 (PubMed).