Trace Amine Associated Receptor 6 (TAAR6) antibody

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  • RP11-295F4.3
  • TA4
  • TAR4
  • TAR6
  • TRAR4
  • taR-4
  • taR-6
  • Ta4
  • Gm228
  • trace amine associated receptor 6
  • trace amine-associated receptor 6
  • TAAR6
  • Taar6
Rat (Rattus), Mouse (Murine), Human
Immunohistochemistry (IHC), Western Blotting (WB)
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Immunogen A synthetic peptide from mouse TAAR6 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TAAR6.
Purification Whole serum
Alternative Name TAAR6 (TAAR6 Antibody Abstract)
Background Function: Orphan receptor. Could be a receptor fortrace amines.trace amines are biogenic amines present in very low levels in mammalian tissues. Although sometrace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta. In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia. Also known as:trace amine-associated receptor 6,trace amine receptor 4, TaR-4, TA4, TAR4, TRAR4, Ta4, Tar4, Trar4.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Lindemann, Ebeling, Kratochwil, Bunzow, Grandy, Hoener: "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors." in: Genomics, Vol. 85, Issue 3, pp. 372-85, 2005 (PubMed).

Duan, Martinez, Sanders, Hou, Saitou, Kitano, Mowry, Crowe, Silverman, Levinson, Gejman: "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia." in: American journal of human genetics, Vol. 75, Issue 4, pp. 624-38, 2004 (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

Borowsky, Adham, Jones, Raddatz, Artymyshyn, Ogozalek, Durkin, Lakhlani, Bonini, Pathirana, Boyle, Pu, Kouranova, Lichtblau, Ochoa, Branchek, Gerald: "Trace amines: identification of a family of mammalian G protein-coupled receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 8966-71, 2001 (PubMed).