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Family with Sequence Similarity 176, Member A (FAM176A) antibody

Details for Product No. ABIN350020, Supplier: Log in to see
Antigen
  • Fam176a
  • RGD1559797
  • Tmem166
  • FAM176A
  • TMEM166
  • BC014699
Reactivity
Human, Mouse (Murine), Rat (Rattus)
27
21
20
1
Host
Rabbit
25
3
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
17
11
6
3
3
Supplier
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Immunogen A synthetic peptide from human transmembrane protein 166 (TM166, TMEM166) conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for TMEM166.
Purification Whole serum
Alternative Name TMEM166 (FAM176A Antibody Abstract)
Background Function: Acts as a regulator of programmed cell death, mediating bothautophagy and apoptosis.
Subcellular location: Endoplasmic reticulum membrane, Single-pass membrane protein. Lysosome membrane, Single-pass membrane protein.
Tissue specificity: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle. Also known as: TM166, TMEM166.
Research Area Cancer, Autophagy, Apoptosis/Necrosis
Application Notes Use at a dilution of 1 : 200 to 1 : 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Wang, Yu, Lu et al.: "TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis." in: Apoptosis : an international journal on programmed cell death, Vol. 12, Issue 8, pp. 1489-502, 2007 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Wan, Gong, Qin et al.: "Large-scale cDNA transfection screening for genes related to cancer development and progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 44, pp. 15724-9, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).