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Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (4th Cytoplasmic Loop) antibody
|Synonyms||TRP5, CCE2, TRP-5, Trrp5, MGC124500, TRPC5, trp, wu:fi73f08|
4th Cytoplasmic Loop
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|6 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||TRPC5 (TRP5, Htrp-5, Htrp5)|
|Immunogen||A synthetic peptide from the 4th cytoplasmic loop of human TRPC5 (TRP5, Htrp-5, Htrp5) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.|
|Description||FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. SUBUNIT: Interacts with NHERF. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain with higher levels in fetal brain. Also known as: Short transient receptor potential channel 5, TrpC5, Htrp-5, trp5, TRP5.|
|Specificity||Appears to be specific for TRPC5.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).
Okada, Shimizu, Wakamori et al.: "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10279-87, 1998 (PubMed).
Sossey-Alaoui, Lyon, Jones et al.: "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel." in: Genomics, Vol. 60, Issue 3, pp. 330-40, 1999 (PubMed).
Tang, Tang, Chen et al.: "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 37559-64, 2000 (PubMed).
Obukhov, Nowycky: "TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50)." in: Journal of cellular physiology, Vol. 201, Issue 2, pp. 227-35, 2004 (PubMed).
Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).
|Hosts||Rabbit (9), Mouse (7), Sheep (4)|
|Reactivities||Human (12), Mouse (Murine) (6), Rat (Rattus) (4), Zebrafish (Danio rerio) (3), Cow (Bovine) (1), Guinea Pig (1)|
|Applications||Western Blotting (WB) (19), Immunohistochemistry (IHC) (12), ELISA (4), Immunofluorescence (IF) (3), Immunohistochemistry (Fixed) (IHC (fx)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunoprecipitation (IP) (3), Immunocytochemistry (ICC) (2), Immunostaining (ISt) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)|
|Epitopes||4th Cytoplasmic Domain (1), 4th Cytoplasmic Loop (1), AA 534-604 (1), AA 827-845 (1), AA 927-845 (1), N-Term (1)|