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Details for Product No. ABIN350021

Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (4th Cytoplasmic Loop) antibody

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Antigen
Synonyms TRP5, CCE2, TRP-5, Trrp5, trp, trpc5, wu:fi73f08, Trpc5, TRPC5
Epitope
»Alternatives 4th Cytoplasmic Loop
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN350021
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 4th cytoplasmic loop of human TRPC5 (TRP5, Htrp-5, Htrp5) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Appears to be specific for TRPC5.
Purity whole serum
Alternative Name TRPC5 (TRP5, Htrp-5, Htrp5)
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain with higher levels in fetal brain. Also known as: Short transient receptor potential channel 5, TrpC5, Htrp-5, trp5, TRP5.
UniProt Q9UL62
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

Okada, Shimizu, Wakamori et al.: "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10279-87, 1998 (PubMed).

Sossey-Alaoui, Lyon, Jones et al.: "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel." in: Genomics, Vol. 60, Issue 3, pp. 330-40, 1999 (PubMed).

Tang, Tang, Chen et al.: "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 37559-64, 2000 (PubMed).

Obukhov, Nowycky: "TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50)." in: Journal of cellular physiology, Vol. 201, Issue 2, pp. 227-35, 2004 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Alternatives for antigen "Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5)", type "Antibodies"
Hosts (14), (12), (5)
Reactivities (24), (10), (9), (3), (1), (1), (1)
Applications (29), (15), (6), (6), (4), (3), (3), (3), (3), (2), (1)
Epitopes (5), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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