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Transient Receptor Potential Cation Channel, Subfamily C, Member 5 (TRPC5) (C-Term), (3rd Extracellular Loop) antibody

Details for Product No. ABIN350021
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Antigen
Synonyms TRP5, CCE2, TRP-5, Trrp5, trp, trpc5, wu:fi73f08, Trpc5, TRPC5
Epitope
C-Term, 3rd Extracellular Loop
(20), (8), (7), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(42), (12), (8), (2), (1), (1)
Host
Sheep
(29), (20), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(49), (36), (19), (19), (12), (4), (3), (2), (1), (1)
Pubmed 6 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350021
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the c-terminal region of human transient receptor potential cation channel subfamily M member 4 (TRPM4, melastatin-4) conjugated to immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPM4.
Purification whole serum
Alternative Name TRPC5 (TRP5, Htrp-5, Htrp5)
Background Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain with higher levels in fetal brain. Also known as: Short transient receptor potential channel 5, TrpC5, Htrp-5, trp5, TRP5.
UniProt Q8TD43
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Zhu, Jiang, Peyton et al.: "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." in: Cell, Vol. 85, Issue 5, pp. 661-71, 1996 (PubMed).

Okada, Shimizu, Wakamori et al.: "Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10279-87, 1998 (PubMed).

Sossey-Alaoui, Lyon, Jones et al.: "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel." in: Genomics, Vol. 60, Issue 3, pp. 330-40, 1999 (PubMed).

Tang, Tang, Chen et al.: "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 37559-64, 2000 (PubMed).

Obukhov, Nowycky: "TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50)." in: Journal of cellular physiology, Vol. 201, Issue 2, pp. 227-35, 2004 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome...." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350021
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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