Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (3rd Cytoplasmic Loop) antibody

Details for Product No. ABIN350022
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Antigen
Synonyms si:dkey-9e15.2, VR.5'sv, Vr1, Vr1l1, VR1, OTRPC1, TRPV1alpha, TRPV1beta, VR-1
Epitope
3rd Cytoplasmic Loop
(17), (16), (10), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(75), (51), (31), (19), (12), (12), (3), (3), (3), (3), (2), (1)
Host
Rabbit
(107), (10), (7), (4), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(88), (69), (19), (12), (11), (10), (8), (6), (4), (3), (1), (1)
Pubmed 7 references available
Quantity 100 μL
Options
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Catalog No. ABIN350022
454.67 $
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Immunogen A synthetic peptide from the 3d cytoplasmic loop of human TRPV1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for TRPV1.
Purification Whole serum
Alternative Name TRPV1
Background Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. Also known as: TrpV1, osm-9-like TRP channel 1, OTRPC1, vanilloid receptor 1, capsaicin receptor, VR1, DKFZp434K0220, transient receptor potential cation channel subfamily V member 1.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Hayes, Meadows, Gunthorpe et al.: "Cloning and functional expression of a human orthologue of rat vanilloid receptor-1." in: Pain, Vol. 88, Issue 2, pp. 205-15, 2001 (PubMed).

McIntyre, McLatchie, Chambers et al.: "Pharmacological differences between the human and rat vanilloid receptor 1 (VR1)." in: British journal of pharmacology, Vol. 132, Issue 5, pp. 1084-94, 2001 (PubMed).

Wiemann, Weil, Wellenreuther et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

Cortright, Crandall, Sanchez et al.: "The tissue distribution and functional characterization of human VR1." in: Biochemical and biophysical research communications, Vol. 281, Issue 5, pp. 1183-9, 2001 (PubMed).

Smith, Gunthorpe, Kelsell et al.: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Staender, Moormann, Schumacher et al.: "Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures." in: Experimental dermatology, Vol. 13, Issue 3, pp. 129-39, 2004 (PubMed).

Gavva, Klionsky, Qu et al.: "Molecular determinants of vanilloid sensitivity in TRPV1." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 20283-95, 2004 (PubMed).

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