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Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (3rd Extracellular Loop) antibody

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Synonyms si:dkey-9e15.2, VR.5'sv, Vr1, Vr1l1, VR1, OTRPC1, TRPV1alpha, TRPV1beta, VR-1
3rd Extracellular Loop
(30), (25), (13), (13), (10), (7), (5), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Guinea Pig
(102), (67), (42), (6), (3), (3), (3), (3), (2), (1)
(143), (11), (8), (7), (1), (1)
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(109), (98), (33), (17), (13), (11), (8), (8), (6), (3), (2)
Pubmed 7 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 3d extracellular loop of human TRPV1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in guinea pig.
Specificity Specific for TRPV1.
Purification Whole serum
Alternative Name TRPV1 (TRPV1 Antibody Abstract)
Background Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. Also known as: TrpV1, osm-9-like TRP channel 1, OTRPC1, vanilloid receptor 1, capsaicin receptor, VR1, DKFZp434K0220, transient receptor potential cation channel subfamily V member 1.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Gavva, Klionsky, Qu et al.: "Molecular determinants of vanilloid sensitivity in TRPV1." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 20283-95, 2004 (PubMed).

Staender, Moormann, Schumacher et al.: "Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures." in: Experimental dermatology, Vol. 13, Issue 3, pp. 129-39, 2004 (PubMed).

Smith, Gunthorpe, Kelsell et al.: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Cortright, Crandall, Sanchez et al.: "The tissue distribution and functional characterization of human VR1." in: Biochemical and biophysical research communications, Vol. 281, Issue 5, pp. 1183-9, 2001 (PubMed).

Wiemann, Weil, Wellenreuther et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

McIntyre, McLatchie, Chambers et al.: "Pharmacological differences between the human and rat vanilloid receptor 1 (VR1)." in: British journal of pharmacology, Vol. 132, Issue 5, pp. 1084-94, 2001 (PubMed).

Hayes, Meadows, Gunthorpe et al.: "Cloning and functional expression of a human orthologue of rat vanilloid receptor-1." in: Pain, Vol. 88, Issue 2, pp. 205-15, 2001 (PubMed).

Catalog No. ABIN350023
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