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Details for Product No. ABIN350030

5HT1A Receptor (Serotonin Receptor 1A) (3rd Cytoplasmic Domain) antibody

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Antigen
Epitope
»Alternatives 3rd Cytoplasmic Domain
Reactivity
Human, Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350030
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the 3d cytoplasmic domain of 5HT1A receptor (Serotonin receptor 1A, Gpcr18, 5-hydroxytryptamine receptor 1A) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 96% identity with rat and human sequence.
Specificity Appears to be specific for 5HT1A receptor.
Purity whole serum
Background Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Most abundantly expressed in midbrain and cortex. Also known as: Serotonin receptor 1A, Gpcr18, 5-hydroxytryptamine receptor 1A, Htr1a.
UniProt Q64264
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Charest, Wainer, Albert: "Cloning and differentiation-induced expression of a murine serotonin1A receptor in a septal cell line." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 13, Issue 12, pp. 5164-71, 1994 (PubMed).

Wilkie, Chen, Gilbert et al.: "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors." in: Genomics, Vol. 18, Issue 2, pp. 175-84, 1994 (PubMed).

Parks, Shenk: "The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 4417-30, 1996 (PubMed).

Alternatives for antigen "5HT1A Receptor (Serotonin Receptor 1A)", type "Antibodies"
Hosts (1)
Applications (1), (1)
Epitopes (1)
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