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Details for Product No. ABIN350031

5HT3A Receptor (5-HT3R, 5-HT-3, Serotonin Receptor 3A) (1st Extracellular Domain) antibody

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1st Extracellular Domain
Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350031
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the 1t extracellular domain of mouse 5HT3A receptor (5-HT3R, 5-HT-3, Serotonin receptor 3A) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 86% identity with rat sequence.
Specificity Appears to be specific for 5HT3A receptor.
Purity whole serum
Background Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular location: Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in central and peripheral neurons. Induction: By nerve growth factor in PC12 cells. Also known as: 5-HT3R, 5-HT-3, Serotonin receptor 3A, Htr3a, 5ht3, Htr3, Serotonin gated ion channel receptor.
UniProt P23979
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Maricq, Peterson, Brake et al.: "Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel." in: Science (New York, N.Y.), Vol. 254, Issue 5030, pp. 432-7, 1991 (PubMed).

Hope, Downie, Sutherland et al.: "Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit." in: European journal of pharmacology, Vol. 245, Issue 2, pp. 187-92, 1993 (PubMed).

Werner, Kawashima, Reid et al.: "Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants." in: Brain research. Molecular brain research, Vol. 26, Issue 1-2, pp. 233-41, 1995 (PubMed).

Uetz, Abdelatty, Villarroel et al.: "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11." in: FEBS letters, Vol. 339, Issue 3, pp. 302-6, 1994 (PubMed).

Kelley, Dunlop, Kirkness et al.: "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors." in: Nature, Vol. 424, Issue 6946, pp. 321-4, 2003 (PubMed).