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5HT3A Receptor (5-HT3R, 5-HT-3, Serotonin Receptor 3A) (Extracellular Domain) antibody

Details for Product No. ABIN350031
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Antigen
Epitope
Extracellular Domain
Reactivity
Mouse (Murine), Rat (Rattus), Human
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Quantity 100 µL
Options
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Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350031
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the 1t extracellular domain of mouse 5HT3A receptor (5-HT3R, 5-HT-3, Serotonin receptor 3A) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 86% identity with rat sequence.
Isotype IgG
Specificity Specific for AKT1, AKT2, AKT3.
Purification whole serum
Background Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular location: Cell junction › synapse › postsynaptic cell membrane, Multi-pass membrane protein. Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in central and peripheral neurons. Induction: By nerve growth factor in PC12 cells. Also known as: 5-HT3R, 5-HT-3, Serotonin receptor 3A, Htr3a, 5ht3, Htr3, Serotonin gated ion channel receptor.
UniProt O57513
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Maricq, Peterson, Brake et al.: "Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel." in: Science (New York, N.Y.), Vol. 254, Issue 5030, pp. 432-7, 1991 (PubMed).

Hope, Downie, Sutherland et al.: "Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit." in: European journal of pharmacology, Vol. 245, Issue 2, pp. 187-92, 1993 (PubMed).

Werner, Kawashima, Reid et al.: "Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants." in: Brain research. Molecular brain research, Vol. 26, Issue 1-2, pp. 233-41, 1995 (PubMed).

Uetz, Abdelatty, Villarroel et al.: "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11." in: FEBS letters, Vol. 339, Issue 3, pp. 302-6, 1994 (PubMed).

Kelley, Dunlop, Kirkness et al.: "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors." in: Nature, Vol. 424, Issue 6946, pp. 321-4, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350031
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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