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Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (N-Term) antibody

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Synonyms als2, si:dkey-33m14.1, ALS2CR6, ALSJ, IAHSP, PLSJ, 3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563
(24), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Rat (Rattus)
(72), (29), (26), (4), (4), (1), (1), (1), (1)
(46), (20), (9)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(46), (33), (25), (12), (11), (3), (2), (1)
Pubmed 3 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal of rat ALS2 (Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for ALS2.
Purification Whole serum
Alternative Name ALS2 (ALS2 Antibody Abstract)
Background Function: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
Subunit: Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL. Also known as: Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Jacquier, Buhler, Schaefer et al.: "Alsin/Rac1 signaling controls survival and growth of spinal motoneurons." in: Annals of neurology, Vol. 60, Issue 1, pp. 105-17, 2006 (PubMed).

Devon, Schwab, Topp et al.: "Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood." in: Neurobiology of disease, Vol. 18, Issue 2, pp. 243-57, 2005 (PubMed).

Gibbs, Weinstock, Metzker et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution. ..." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004 (PubMed).

Catalog No. ABIN350038
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