Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (N-Term) antibody

Antigen: Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)

Synonyms: ALSJ, PLSJ, IAHSP, ALS2CR6, FLJ31851, KIAA1563, MGC87187, als2, si:dkey-33m14.1

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350038

Additional Information

Alternative name: ALS2 (Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog) (n-terminal)

Swiss-Prot: P0C5Y8

Immunogen: A synthetic peptide from the n-terminal of rat ALS2 (Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons. SUBUNIT: Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL. Also known as: Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog.

Specificity: Appears to be specific for ALS2.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Gibbs, Weinstock, Metzker et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004 (PubMed).

Devon, Schwab, Topp et al.: "Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood." in: Neurobiology of disease, Vol. 18, Issue 2, pp. 243-57, 2005 (PubMed).

Jacquier, Buhler, Schaefer et al.: "Alsin/Rac1 signaling controls survival and growth of spinal motoneurons." in: Annals of neurology, Vol. 60, Issue 1, pp. 105-17, 2006 (PubMed).