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Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (N-Term) antibody

Details for Product No. ABIN350039, Supplier: Log in to see
Antigen
  • 3222402C23Rik
  • 9430073A21Rik
  • als2
  • ALS2CR6
  • Als2cr6
  • Alsin
  • ALSJ
  • IAHSP
  • mKIAA1563
  • PLSJ
  • si:dkey-33m14.1
Epitope
N-Term
22
5
4
3
2
2
2
2
2
1
1
1
Reactivity
Rat (Rattus)
68
29
26
4
4
1
1
1
1
Host
Rabbit
43
19
9
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
43
31
23
11
10
3
2
1
Supplier
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Immunogen A synthetic peptide from the n-terminal of rat ALS2 (Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Specific for ALS2.
Alternative Name ALS2 (ALS2 Antibody Abstract)
Background Function: May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
Subunit: Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL. Also known as: Alsin, Alsin2, Amyotrophic lateral sclerosis protein 2 homolog.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Jacquier, Buhler, Schaefer, Bohl, Blanchard, Beclin, Haase: "Alsin/Rac1 signaling controls survival and growth of spinal motoneurons." in: Annals of neurology, Vol. 60, Issue 1, pp. 105-17, 2006

Devon, Schwab, Topp, Orban, Yang, Pape, Helm, Davidson, Rogers, Gros-Louis, Rouleau, Horazdovsky, Leavitt, Hayden: "Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood." in: Neurobiology of disease, Vol. 18, Issue 2, pp. 243-57, 2005

Gibbs, Weinstock, Metzker, Muzny, Sodergren, Scherer, Scott, Steffen, Worley, Burch, Okwuonu, Hines, Lewis, DeRamo, Delgado, Dugan-Rocha, Miner, Morgan, Hawes, Gill, Celera, Holt, Adams, Amanatides et al.: "Genome sequence of the Brown Norway rat yields insights into mammalian evolution. ..." in: Nature, Vol. 428, Issue 6982, pp. 493-521, 2004