Alstrom Syndrome 1 (ALMS1) (C-Term) antibody

Details for Product No. ABIN350040
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Antigen
Synonyms ALSS, bbb, ALMS1
Epitope
C-Term
(5), (4)
Reactivity
Human
(14), (2), (1), (1), (1)
Host
Rabbit
(10), (6)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(12), (11), (5), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN350040
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from C-terminal region of mouse Alstrom syndrome protein 1 homolog (ALMS1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for DFNA5.
Purification whole serum
Alternative Name Alstrom syndrome protein 1 homolog (ALMS1)
Background Function: Possible role in intracellular trafficking.
Subcellular location: Cytoplasm. Centrosome. Cell projection, cilium basal body. Note: Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
Tissue specificity: Ubiquitously expressed.
Developmental stage: Expressed at E7.5. At E8.0 expression is found in mesodermal- and ectodermal-derived layers. At E10.5 mainly detected in midbrain, hindbrain, forelimb and hindlimb. Also expressed at E15.5 and E18.5.
Miscellaneous: Mice lacking Alms1 display obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and hearing loss. Also known as: ALMS1.
UniProt O60443
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Collin, Marshall, Ikeda et al.: "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome." in: Nature genetics, Vol. 31, Issue 1, pp. 74-8, 2002 (PubMed).

Okazaki, F-Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 3, pp. 205-18, 2004 (PubMed).

Collin, Cyr, Bronson et al.: "Alms1-disrupted mice recapitulate human Alström syndrome." in: Human molecular genetics, Vol. 14, Issue 16, pp. 2323-33, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Dai, Jin, Sheng et al.: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).

Hosts (10), (6)
Reactivities (14), (2), (1), (1), (1)
Applications (12), (11), (5), (2), (1), (1)
Epitopes (5), (4)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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