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Alstrom Syndrome 1 (ALMS1) (C-Term) antibody
|Synonyms||ALSS, KIAA0328, DKFZp686A118, DKFZp686D1828, bbb, ALMS1|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Alstrom syndrome protein 1 homolog (ALMS1)|
|Immunogen||A synthetic peptide from C-terminal part of mouse Alstrom syndrome protein 1 homolog (ALMS1) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: Possible role in intracellular trafficking. SUBCELLULAR LOCATION: Cytoplasm. Centrosome. Cell projection, cilium basal body. Note: Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles. TISSUE SPECIFICITY: Ubiquitously expressed. DEVELOPMENTAL STAGE: Expressed at E7.5. At E8.0 expression is found in mesodermal- and ectodermal-derived layers. At E10.5 mainly detected in midbrain, hindbrain, forelimb and hindlimb. Also expressed at E15.5 and E18.5. MISCELLANEOUS: Mice lacking Alms1 display obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and hearing loss. Also known as: ALMS1.|
|Specificity||Appears to be specific for ALMS1.|
|Application Notes||IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Collin, Marshall, Ikeda et al.: "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome." in: Nature genetics, Vol. 31, Issue 1, pp. 74-8, 2002 (PubMed).
Okazaki, F-Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 3, pp. 205-18, 2004 (PubMed).
Collin, Cyr, Bronson et al.: "Alms1-disrupted mice recapitulate human Alström syndrome." in: Human molecular genetics, Vol. 14, Issue 16, pp. 2323-33, 2005 (PubMed).
Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).
Dai, Jin, Sheng et al.: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).
|Hosts||Goat (4), Rabbit (2)|
|Reactivities||Human (5), Cow (Bovine) (1), Dog (Canine) (1), Mouse (Murine) (1), Rat (Rattus) (1)|
|Applications||ELISA (4), Western Blotting (WB) (3), Immunohistochemistry (IHC) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)|
|Epitopes||C-Term (1), Internal Region (1)|