Amiloride-Sensitive Cation Channel 1, Neuronal (ACCN1) (C-Term) antibody

Details for Product No. ABIN350041
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Antigen
Synonyms Bnc, AI047752, AW546376, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, ACIC2, Accn1, BNaC1a, Mdeg, BNC1k, MDEG1, MDEG2, accn1, zASIC2
Epitope
C-Term
(6), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(34), (20), (18), (14), (13), (1)
Host
Rabbit
(38), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(25), (10), (10), (7), (3), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN350041
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from c-terminal region of human amiloride sensitive cation channel 1, neuronal (ACCN1, ASIC2) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for GLUT-3.
Purification whole serum
Alternative Name amiloride sensitive cation channel 1, neuronal (ACCN1, ASIC2)
Background Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subunit: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM. Interacts with PRKCABP and ACCN3.
Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. Also known as: Amiloride-sensitive brain sodium channel, acid-sensing ion channel 2, ASIC2, brain sodium channel 1, BNaC1, BNC1, mammalian degenerin homolog, ACCN, BNAC1, MDEG.
UniProt Q07647
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Price, Snyder, Welsh: "Cloning and expression of a novel human brain Na+ channel." in: The Journal of biological chemistry, Vol. 271, Issue 14, pp. 7879-82, 1996 (PubMed).

Waldmann, Champigny, Voilley et al.: "The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans." in: The Journal of biological chemistry, Vol. 271, Issue 18, pp. 10433-6, 1996 (PubMed).

Garcuia-Aunoveros, Derfler, Neville-Golden et al.: "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 4, pp. 1459-64, 1997 (PubMed).

Babinski, Catarsi, Biagini et al.: "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+." in: The Journal of biological chemistry, Vol. 275, Issue 37, pp. 28519-25, 2000 (PubMed).

Hruska-Hageman, Wemmie, Price et al.: "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 443-50, 2002 (PubMed).

Hosts (38), (3), (1)
Reactivities (34), (20), (18), (14), (13), (1)
Applications (25), (10), (10), (7), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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