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Details for Product No. ABIN350048

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN1) (Extracellular Domain) antibody

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Antigen
Synonyms ACCN2, ASIC, BNaC2, AI843610, ASIC1a, Accn2, B530003N02Rik, ASIC1
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Rat (Rattus), Human, Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 10 references available
Catalog no. ABIN350048
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the extracellular domain of rat amiloride sensitive cation channel 2, neuronal (ACCN2, ASIC1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse and shares 96% identity with human's.
Specificity Appears to be specific for ASIC1.
Purity whole serum
Alternative Name amiloride sensitive cation channel 2, neuronal (ACCN2, ASIC1)
Background This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobictransmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit, however, its function as an ion channel remains unknown.
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+).
Subcellular location: Cell membrane, Multi-pass membrane protein. Note=Localizes in synaptosomes at dendritic synapses of neurons.
Tissue specificity: Expressed in dorsal root ganglia (DRG) and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed inolfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion  while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus. Also known as: Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, ACCN2.
UniProt P55926
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Waldmann, Champigny, Bassilana et al.: "A proton-gated cation channel involved in acid-sensing." in: Nature, Vol. 386, Issue 6621, pp. 173-7, 1997 (PubMed).

Bassilana, Champigny, Waldmann et al.: "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 28819-22, 1997 (PubMed).

Chen, England, Akopian et al.: "A sensory neuron-specific, proton-gated ion channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 17, pp. 10240-5, 1998 (PubMed).

Askwith, Cheng, Ikuma et al.: "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels." in: Neuron, Vol. 26, Issue 1, pp. 133-41, 2000 (PubMed).

Escoubas, De Weille, Lecoq et al.: "Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25116-21, 2000 (PubMed).

Baessler, Ngo-Anh, Geisler et al.: "Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b." in: The Journal of biological chemistry, Vol. 276, Issue 36, pp. 33782-7, 2001 (PubMed).

Voilley, de Weille, Mamet et al.: "Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 20, pp. 8026-33, 2001 (PubMed).

Ugawa, Ueda, Takahashi et al.: "Cloning and functional expression of ASIC-beta2, a splice variant of ASIC-beta." in: Neuroreport, Vol. 12, Issue 13, pp. 2865-9, 2001 (PubMed).

Babini, Paukert, Geisler et al.: "Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1)." in: The Journal of biological chemistry, Vol. 277, Issue 44, pp. 41597-603, 2002 (PubMed).

Coric, Zhang, Todorovic et al.: "The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 45240-7, 2003 (PubMed).

Alternatives for antigen "Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN1)", type "Antibodies"
Hosts (54), (3), (2), (1)
Reactivities (50), (47), (45), (36), (35), (17), (17)
Applications (34), (31), (20), (12), (12), (10), (3), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (7), (6), (5), (2), (2), (1), (1)
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