Amiloride-Sensitive Cation Channel 5, Intestinal (ACCN5) (cytoplasmic domain) antibody

Antigen: Amiloride-Sensitive Cation Channel 5, Intestinal (ACCN5)

Synonyms: INAC, HINAC, Inac, Blinac, ACCN5

Epitope: cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350053

Additional Information

Alternative name: amiloride sensitive cation channel 5, neuronal (ACCN5) (cytoplasmic domain)

Swiss-Prot: Q9NY37

Immunogen: A synthetic peptide from the cytoplasmic domain of human amiloride sensitive cation channel 5, neuronal (ACCN5) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. Tissue specificity: Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Also known as: Human intestine Na(+) channel, HINaC, ACCN5.

Specificity: Appears to be specific for ACCN5.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Schaefer, Sakai, Mattei et al.: "Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine." in: FEBS letters, Vol. 471, Issue 2-3, pp. 205-10, 2000 (PubMed).