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Details for Product No. ABIN350060

Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (Extracellular Domain) antibody

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Antigen
Synonyms ENaCd, ENaCdelta, SCNED, dNaCh, Scnn1d, SCNN1D
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN350060
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for VDP.
Purity whole serum
Alternative Name amiloride sensitive sodium channel subunit delta (SCNN1D)
Background Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Epithelial Na(+) channel subunit delta, delta-ENaC, nonvoltage-gated sodium channel 1 subunit delta, SCNED, delta-NaCH, dNaCh, ENaCdelta, MGC149710, MGC149711, DNACH.
UniProt Q9Z1Z0
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Waldmann, Champigny, Bassilana et al.: "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel." in: The Journal of biological chemistry, Vol. 270, Issue 46, pp. 27411-4, 1996 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Alternatives for antigen "Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D)", type "Antibodies"
Hosts (52), (3), (2)
Reactivities (57)
Applications (30), (25), (20), (20), (9), (7), (1), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (6), (3), (3), (2), (2), (1), (1), (1), (1)
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