Sodium Channel, Nonvoltage-Gated 1, delta (SCNN1D) (Extracellular Domain) antibody

Details for Product No. ABIN350060
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Antigen
Synonyms Scnn1d, SCNN1D, ENaCd, ENaCdelta, SCNED, dNaCh
Epitope
Extracellular Domain
(7), (7), (7), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(58)
Host
Rabbit
(52), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC)
(34), (25), (20), (11), (11), (8), (3), (1), (1)
Pubmed 3 references available
Quantity 100 μL
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Catalog No. ABIN350060
454.67 $
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Immunogen A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SCNN1D.
Purification Whole serum
Alternative Name SCNN1D
Background Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit.
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Epithelial Na(+) channel subunit delta, delta-ENaC, nonvoltage-gated sodium channel 1 subunit delta, SCNED, delta-NaCH, dNaCh, ENaCdelta, MGC149710, MGC149711, DNACH.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Waldmann, Champigny, Bassilana et al.: "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel." in: The Journal of biological chemistry, Vol. 270, Issue 46, pp. 27411-4, 1996 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

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