Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) (Extracellular Domain) antibody

Details for Product No. ABIN350062
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Antigen
Synonyms scnn1g, MGC81424, SCNN1G, ENaCgamma, BESC3, ENaCg, PHA1, SCNEG, GAMMA-ENAC, [g]ENaC, ENaC
Epitope
Extracellular Domain
(26), (19), (4), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(44), (36), (20), (12)
Host
Rabbit
(53), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(44), (30), (19), (19), (10), (9), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μL
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Catalog No. ABIN350062
454.67 $
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Immunogen A synthetic peptide from the extracellular domain of mouse amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC) conjugated to immunogenic carrier protein was used as the immunogen.
Specificity Specific for SCNN1G.
Purification Whole serum
Alternative Name SCNN1G
Background Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note: Apical membrane of epithelial cells. PTM: Phosphorylated on serine and threonine residues. PTM: Ubiquitinated, this targets individual subunits for endocytosis and proteasome-mediated degradation. DISEASE: Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Also known as: Amiloride-sensitive sodium channel subunit gamma (SCNN1G, SCNEG), Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, PHA1, ENaCg, SCNEG, ENaCgamma.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Ahn, Brooker, Kosari et al.: "Cloning and functional expression of the mouse epithelial sodium channel." in: The American journal of physiology, Vol. 277, Issue 1 Pt 2, pp. F121-9, 1999 (PubMed).

Harvey, Dinudom, Cook et al.: "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 8597-601, 2001 (PubMed).

Fotia, Dinudom, Shearwin et al.: "The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 1, pp. 70-2, 2003 (PubMed).

Fotia, Ekberg, Adams et al.: "Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28930-5, 2004 (PubMed).

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