Did you know that you can buy products from over 140 different suppliers from us?

Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) (Extracellular Domain) antibody

Details for Product No. ABIN350063
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms BESC3, ENaCg, ENaCgamma, PHA1, SCNEG, ENaC, [g]ENaC, GAMMA-ENAC, scnn1g, MGC81424, SCNN1G
Epitope
Extracellular Domain
(25), (18), (3), (3), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine)
(48), (39), (26), (17)
Host
Sheep
(55), (5), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC)
(41), (28), (22), (18), (14), (10), (2), (1), (1)
Pubmed 4 references available
Quantity 100 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 7 to 8 Business Days
Catalog No. ABIN350063
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the extracellular domain of rat amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC) conjugated to immunogenic carrier protein was used as the immunogen. The antigen shares 94% identity with mouse's.
Isotype IgG
Specificity Specific for Runx3.
Purification This product was prepared from monospecific antiserum by immunoaffinity chromatography using Mouse IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Sheep Serum, Mouse IgG and Mouse Serum.
whole serum
Alternative Name amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC)
Background Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note: Apical membrane of epithelial cells. PTM: Phosphorylated on serine and threonine residues. PTM: Ubiquitinated, this targets individual subunits for endocytosis and proteasome-mediated degradation. DISEASE: Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Also known as: Amiloride-sensitive sodium channel subunit gamma (SCNN1G, SCNEG), Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, PHA1, ENaCg, SCNEG, ENaCgamma.
UniProt Q64131
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Lingueglia, Renard, Waldmann et al.: "Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone." in: The Journal of biological chemistry, Vol. 269, Issue 19, pp. 13736-9, 1994 (PubMed).

Kreutz, Struk, Rubattu et al.: "Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension." in: Hypertension, Vol. 29, Issue 1 Pt 1, pp. 131-6, 1997 (PubMed).

Staub, Gautschi, Ishikawa et al.: "Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination." in: The EMBO journal, Vol. 16, Issue 21, pp. 6325-36, 1998 (PubMed).

Shimkets, Lifton, Canessa: "In vivo phosphorylation of the epithelial sodium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 6, pp. 3301-5, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350063
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
Did you look for something else?
back to top