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Details for Product No. ABIN350063

Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G) (Extracellular Domain) antibody

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Antigen
Synonyms BESC3, ENaCg, ENaCgamma, PHA1, SCNEG, ENaC, [g]ENaC, GAMMA-ENAC, scnn1g, MGC81424, SCNN1G
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Rat (Rattus), Mammalian
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN350063
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the extracellular domain of rat amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC) conjugated to immunogenic carrier protein was used as the immunogen. The antigen shares 94% identity with mouse's.
Specificity Appears to be specific for SCNN1G.
Purification This product was prepared from monospecific antiserum by immunoaffinity chromatography using Mouse IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Sheep Serum, Mouse IgG and Mouse Serum.
Purity whole serum
Alternative Name amiloride sensitive sodium channel subunit gamma (SCNN1G, SCNEG, Gamma-ENaC)
Background Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subunit: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note: Apical membrane of epithelial cells. PTM: Phosphorylated on serine and threonine residues. PTM: Ubiquitinated, this targets individual subunits for endocytosis and proteasome-mediated degradation. DISEASE: Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Also known as: Amiloride-sensitive sodium channel subunit gamma (SCNN1G, SCNEG), Epithelial Na(+) channel subunit gamma, Gamma-ENaC, Gamma-NaCH, PHA1, ENaCg, SCNEG, ENaCgamma.
UniProt P37091
Application Notes IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Lingueglia, Renard, Waldmann et al.: "Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone." in: The Journal of biological chemistry, Vol. 269, Issue 19, pp. 13736-9, 1994 (PubMed).

Kreutz, Struk, Rubattu et al.: "Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension." in: Hypertension, Vol. 29, Issue 1 Pt 1, pp. 131-6, 1997 (PubMed).

Staub, Gautschi, Ishikawa et al.: "Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination." in: The EMBO journal, Vol. 16, Issue 21, pp. 6325-36, 1998 (PubMed).

Shimkets, Lifton, Canessa: "In vivo phosphorylation of the epithelial sodium channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 6, pp. 3301-5, 1998 (PubMed).

Alternatives for antigen "Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G)", type "Antibodies"
Hosts (40), (7), (2)
Reactivities (40), (30), (25), (17)
Applications (25), (25), (14), (11), (10), (10), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (3), (2), (2), (2), (1), (1)
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