AMRA1 (AMBRA1) (Extracellular Domain) antibody

Details for Product No. ABIN350067
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Antigen
Epitope
Extracellular Domain
(2)
Reactivity
Human
(2), (2)
Host
Goat
(2)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(2), (2)
Pubmed 5 references available
Catalog no. ABIN350067
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Shipping to United States (Change)
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from the extracellular domain of mouse amiloride sensitive cation channel 1, neuronal (ACCN1, ASIC2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.
Specificity Specific for TLR9.
Purification whole serum
Background Function: Regulatesautophagy and development of the nervous system. Involved inautophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
Subcellular location: Cytoplasmic vesicle › autophagosome Also known as: Activating molecule in BECN1-regulatedautophagy protein 1, AMBRA1, AMRA1.
UniProt Q9NR96
Research Area Immunology, Innate Immunity, Signaling, Inflammation
Application Notes Use at a dilution of 1 : 200 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Nagase, Kikuno, Hattori et al.: "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 6, pp. 347-55, 2001 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Fimia, Stoykova, Romagnoli et al.: "Ambra1 regulates autophagy and development of the nervous system." in: Nature, Vol. 447, Issue 7148, pp. 1121-5, 2007 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Daub, Olsen, Bairlein et al.: "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." in: Molecular cell, Vol. 31, Issue 3, pp. 438-48, 2008 (PubMed).

Hosts (2)
Reactivities (2), (2)
Applications (2), (2)
Epitopes (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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