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AMRA1 (AMBRA1) (Internal Region) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||150 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide from the internal region of human Activating molecule in BECN1 regulated autophagy protein 1 (AMBRA1, AMRA1) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in mouse.|
|Description||Function: Regulatesautophagy and development of the nervous system. Involved inautophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Subcellular location: Cytoplasmic vesicle › autophagosome Also known as: Activating molecule in BECN1-regulatedautophagy protein 1, AMBRA1, AMRA1.|
|Specificity||Appears to be specific for AMBRA1.|
|Application Notes||IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Nagase, Kikuno, Hattori et al.: "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 6, pp. 347-55, 2001 (PubMed).
Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).
Fimia, Stoykova, Romagnoli et al.: "Ambra1 regulates autophagy and development of the nervous system." in: Nature, Vol. 447, Issue 7148, pp. 1121-5, 2007 (PubMed).
Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).
Daub, Olsen, Bairlein et al.: "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." in: Molecular cell, Vol. 31, Issue 3, pp. 438-48, 2008 (PubMed).
|Applications||Immunohistochemistry (IHC) (2), Western Blotting (WB) (2)|
|Epitopes||C-Term (1), Internal Region (1)|