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Arc antibody (Activity-Regulated Cytoskeleton-Associated Protein)

Details for Product anti-Arc Antibody No. ABIN350079, Supplier: Log in to see
Antigen
  • ARC
  • Arc3.1
  • ARG3.1
  • arg3.1
  • Arg3.1
  • C86064
  • mArc
  • rg3.1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
18
6
6
Host
Sheep
18
1
Clonality
Polyclonal
Conjugate
This Arc antibody is un-conjugated
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
11
8
5
2
1
1
1
Supplier
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Immunogen Synthetic peptides from human Arg3.1 (ARC) was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Specific for Arg3.1/ARC.
Purification Whole serum
Alternative Name Arg3.1 (ARC) (Arc Antibody Abstract)
Background Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular location: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note: associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, KIAA0278, Arg3.1/ARC,.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Tan, Ruettiger, Panford-Walsh, Singer, Schulze, Kilian, Hadjab, Zimmermann, Koepschall, Rohbock, Knipper: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007

Chowdhury, Shepherd, Okuno, Lyford, Petralia, Plath, Kuhl, Huganir, Worley: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006

Rial Verde, Lee-Osbourne, Worley, Malinow, Cline: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006

Shepherd, Rumbaugh, Wu, Chowdhury, Plath, Kuhl, Huganir, Worley: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006