Activity-Regulated Cytoskeleton-Associated Protein (Arc) antibody

Details for Product No. ABIN350081
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Antigen
Synonyms Arg3.1, rg3.1, ARG3.1, ARC, arg3.1
Reactivity
Human
(7), (7), (5), (1)
Host
Rabbit
(9), (2), (2), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(12), (7), (6), (6), (5), (4), (1), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN350081
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from rat Arg3.1 (ARC) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for MRGPRD.
Purification whole serum
Alternative Name Arg3.1 (ARC)
Background Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular location: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note: associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arg3.1/ARC,.
UniProt Q8TDS7
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Chowdhury, Shepherd, Okuno et al.: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006 (PubMed).

Rial Verde, Lee-Osbourne, Worley et al.: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006 (PubMed).

Shepherd, Rumbaugh, Wu et al.: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006 (PubMed).

Tan, Ruettiger, Panford-Walsh et al.: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007 (PubMed).

Hosts (9), (2), (2), (1)
Reactivities (7), (7), (5), (1)
Applications (12), (7), (6), (6), (5), (4), (1), (1), (1), (1)
Epitopes (3), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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