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Details for Product No. ABIN350088

Autophagy Related 12 (ATG12) antibody

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Antigen
Synonyms APG12, FBR93, APG12L, HAPG12, Apg12l, Atg12l, 4931423H11Rik, A330058M13Rik
Reactivity
»Alternatives Rat (Rattus), Mouse (Murine)
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350088
Quantity 150 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from rat, mouse ATG12 (APG12, APG12L, HAPG12) conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for ATG12.
Purity whole serum
Alternative Name autophagy related protein 12 (ATG12, APG12, APG12L, HAPG12)
Background Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved inautophagy. Following conjugation to ATG5, the conjugate participates in the formation of autophagosome. Also known as: APG12-like, HAPG12, APG12, ATG12autophagy related 12 homolog.
UniProt Q2TBJ5
Research Area Autophagy
Application Notes IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Tanida, Tanida-Miyake, Komatsu et al.: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

Tanida, Nishitani, Nemoto et al.: "Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing." in: Biochemical and biophysical research communications, Vol. 296, Issue 5, pp. 1164-70, 2002 (PubMed).

Mizushima, Yoshimori, Ohsumi: "Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method." in: FEBS letters, Vol. 532, Issue 3, pp. 450-4, 2002 (PubMed).

Mizushima, Kuma, Kobayashi et al.: "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate." in: Journal of cell science, Vol. 116, Issue Pt 9, pp. 1679-88, 2003 (PubMed).

Prigione, Cortopassi: "Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12." in: Autophagy, Vol. 3, Issue 4, pp. 377-80, 2007 (PubMed).

Alternatives for antigen "Autophagy Related 12 (ATG12)", type "Antibodies"
Hosts (79), (8), (4), (1)
Reactivities (76), (43), (39), (13), (13), (13), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (81), (40), (35), (17), (16), (10), (5), (5), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (22), (7), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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