ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) (isoforms 1 2 3) antibody

Antigen: ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1)

Synonyms: IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677, Apg16l, Atg16l, AI035639, AI225866, 1500009K01Rik, Wdr30, atg16, atg16l

Epitope: isoforms 1 2 3

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350098

Additional Information

Alternative name: autophagy-related protein 16-1 (ATG16L1, APG16L) isoforms 1, 2, 3

Swiss-Prot: Q676U5

Immunogen: A synthetic peptide as a part of human, monkey autophagy-related protein 16-1 (ATG16L1, APG16L) isoforms 1, 2, 3 conjugated to an immunogenic carrier protein has been used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Plays an essential role inautophagy. SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease. Also known as: ATG16L1, APG16L, IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677.

Specificity: Appears to be specific for ATG16L1.

Application Details

Application Notes: IHC, WB. Use at a dilution of 1 : 100 to 1 : 2000. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Research Area: Autophagy

Restrictions: For Research Use only

Publications

Publications: Perricone, Borgiani, Romano et al.: "ATG16L1 Ala197Thr is not associated with susceptibility to Crohn's disease or with phenotype in an Italian population." in: Gastroenterology, Vol. 134, Issue 1, pp. 368-70, 2008 (PubMed).

Van Limbergen, Russell, Nimmo et al.: "Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease." in: Inflammatory bowel diseases, Vol. 15, Issue 10, pp. 1492-8, 2009 (PubMed).