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ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) antibody

Details for Product No. ABIN350100
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Antigen
Synonyms atg16, atg16l, APG16L, ATG16A, ATG16L, IBD10, WDR30, 1500009K01Rik, Apg16l, Atg16l, Wdr30
Reactivity
Mouse (Murine)
(130), (71), (57), (33), (14), (10), (6), (2), (1)
Host
Rabbit
(122), (9), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(96), (38), (30), (25), (20), (11), (9), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 150 µL
Options
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Catalog No. ABIN350100
454.67 $
Plus shipping costs $45.00

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Immunogen A synthetic peptide from mouse APG16L conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for ATG16L1.
Purification Whole serum
Alternative Name APG16L
Background Function: Plays an essential role inautophagy.
Subunit: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa).
Subcellular location: Cytoplasm. Preautophagosomal structure membrane, Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease. Also known as: ATG16L1, APG16L, IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677.
Application Notes Use at a dilution of 1 : 100 to 1 : 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Mizushima, Kuma, Kobayashi et al.: "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate." in: Journal of cell science, Vol. 116, Issue Pt 9, pp. 1679-88, 2003 (PubMed).

Okazaki, Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 2, pp. 127-35, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Validation Images
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