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Details for Product No. ABIN350100

Autophagy-Related Protein (Atg16l1, APG16L) , 2, 3, 4, 5 antibody

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Antigen
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350100
Quantity 150 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of mouse autophagy-related protein 16-1 (Atg16l1, APG16L) isoforms 1, 2, 3, 4, 5 conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for ATG16L1.
Purity whole serum
Background Function: Plays an essential role inautophagy.
Subunit: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa).
Subcellular location: Cytoplasm. Preautophagosomal structure membrane, Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease. Also known as: ATG16L1, APG16L, IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677.
UniProt Q8C0J2
Research Area Autophagy
Application Notes IHC, WB. Use at a dilution of 1 : 100 to 1 : 2000. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Mizushima, Kuma, Kobayashi et al.: "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate." in: Journal of cell science, Vol. 116, Issue Pt 9, pp. 1679-88, 2003 (PubMed).

Okazaki, Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 2, pp. 127-35, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Villén, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).

Alternatives for antigen "Autophagy-Related Protein (Atg16l1, APG16L) , 2, 3, 4, 5", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1)
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