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Details for Product No. ABIN350112

Growth Associated Protein 43 (GAP43) (pSer41) antibody

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Antigen
Synonyms B-50, PP46, Basp2, GAP-43, cb310, gap, gap43, gap43a, pp46, gap-43, MGC64520
Epitope
»Alternatives pSer41
Reactivity
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN350112
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide to phospho S41 of human Axonal membrane protein GAP-43 (Neuromodulin, growth-associated protein 43) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse, zebra fish and chicken.
Isotype IgG
Specificity Appears to be specific for GAP-43.
Purity IgG
Alternative Name Axonal membrane protein GAP-43 (Neuromodulin, growth-associated protein 43)
Background Function: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons.
Subunit: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
Subcellular location: Cell membrane, Peripheral membrane protein, Cytoplasmic side. Cell projection, growth cone membrane, Peripheral membrane protein, Cytoplasmic side. Cell junction, synapse. Note: Cytoplasmic surface of growth cone and synaptic plasma membranes. Also known as: Neuromodulin, growth-associated protein 43, protein F1, Basp2, B-50.
UniProt P17677
Application Notes IHC. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Restrictions For Research Use only
Format Lyophilized
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Cimler, Giebelhaus, Wakim et al.: "Characterization of murine cDNAs encoding P-57, a neural-specific calmodulin-binding protein." in: The Journal of biological chemistry, Vol. 262, Issue 25, pp. 12158-63, 1987 (PubMed).

Ballif, Villén, Beausoleil et al.: "Phosphoproteomic analysis of the developing mouse brain." in: Molecular & cellular proteomics : MCP, Vol. 3, Issue 11, pp. 1093-101, 2004 (PubMed).

Vosseller, Hansen, Chalkley et al.: "Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol." in: Proteomics, Vol. 5, Issue 2, pp. 388-98, 2005 (PubMed).

Trinidad, Specht, Thalhammer et al.: "Comprehensive identification of phosphorylation sites in postsynaptic density preparations." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 5, pp. 914-22, 2006 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Alternatives for antigen "Growth Associated Protein 43 (GAP43)", type "Antibodies"
Hosts (144), (26), (5), (3)
Reactivities (129), (115), (93), (47), (19), (8), (6), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Applications (107), (53), (52), (35), (30), (28), (21), (20), (20), (9), (7), (5), (3), (1)
Conjugates (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (41), (15), (12), (7), (5), (4), (2), (1), (1), (1), (1)
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