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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (Internal Region) antibody
|Synonyms||NIX, BNIP3a, Nix|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||BNIP3L (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like)|
|Immunogen||A synthetic peptide from the internal region of rat BNIP3L (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and mouse.|
|Description||FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3. Subcellular location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane; Single-pass membrane protein Also known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, NIP3-like protein X, NIP3L, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, Adenovirus E1B19K-binding protein B5, BNIP3A, BNIP3H, NIX.|
|Specificity||Appears to be specific for BNIP3L.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Matsushima, Fujiwara, Takahashi et al.: "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3." in: Genes, chromosomes & cancer, Vol. 21, Issue 3, pp. 230-5, 1998 (PubMed).
Chen, Cizeau, Vande Velde et al.: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).
Passer, Nancy-Portebois, Amzallag et al.: "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2284-9, 2003 (PubMed).
Aerbajinai, Giattina, Lee et al.: "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation." in: Blood, Vol. 102, Issue 2, pp. 712-7, 2003 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
|Hosts||Rabbit (40), Mouse (1)|
|Reactivities||Human (39), Mouse (Murine) (22), Cow (Bovine) (18), Horse (Equine) (18), Pig (Porcine) (18), Rat (Rattus) (18)|
|Applications||Western Blotting (WB) (22), Immunofluorescence (IF) (15), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (IHC) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 77-92 (4), Center (3), Internal Region (2), AA 7-7 (1), internal (1)|