BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (Internal Region) antibody

Details for Product No. ABIN350121
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Antigen
Synonyms BNIP3a, NIX, C86132, D14Ertd719e, Nip3L, Nix
Epitope
Internal Region
(15), (10), (7), (3), (3), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(63), (20), (12), (12), (12), (1)
Host
Rabbit
(62), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(46), (21), (20), (18), (10), (7), (7), (5), (5), (1)
Pubmed 5 references available
Quantity 100 µL
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Catalog No. ABIN350121
454.67 $
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Immunogen A synthetic peptide from the internal region of rat BNIP3L (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and mouse.
Specificity Specific for BNIP3L.
Purification Whole serum
Alternative Name BNIP3L
Background Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
Subcellular location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane, Single-pass membrane protein Also known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, NIP3-like protein X, NIP3L, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, Adenovirus E1B19K-binding protein B5, BNIP3A, BNIP3H, NIX.
Research Area Cancer, Apoptosis/Necrosis
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Matsushima, Fujiwara, Takahashi et al.: "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3." in: Genes, chromosomes & cancer, Vol. 21, Issue 3, pp. 230-5, 1998 (PubMed).

Chen, Cizeau, Vande Velde et al.: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).

Passer, Nancy-Portebois, Amzallag et al.: "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2284-9, 2003 (PubMed).

Aerbajinai, Giattina, Lee et al.: "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation." in: Blood, Vol. 102, Issue 2, pp. 712-7, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

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