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Details for Product No. ABIN350121

BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L) (Internal Region) antibody

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Antigen
Synonyms NIX, BNIP3a, Nix
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Rat (Rattus), Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350121
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal region of rat BNIP3L (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in human and mouse.
Specificity Appears to be specific for BNIP3L.
Purity whole serum
Alternative Name BNIP3L (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like)
Background Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
Subcellular location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane, Single-pass membrane protein Also known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, NIP3-like protein X, NIP3L, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, Adenovirus E1B19K-binding protein B5, BNIP3A, BNIP3H, NIX.
UniProt Q8VBW4
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Matsushima, Fujiwara, Takahashi et al.: "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3." in: Genes, chromosomes & cancer, Vol. 21, Issue 3, pp. 230-5, 1998 (PubMed).

Chen, Cizeau, Vande Velde et al.: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).

Passer, Nancy-Portebois, Amzallag et al.: "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2284-9, 2003 (PubMed).

Aerbajinai, Giattina, Lee et al.: "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation." in: Blood, Vol. 102, Issue 2, pp. 712-7, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L)", type "Antibodies"
Hosts (57), (4)
Reactivities (58), (18), (12), (12), (12)
Applications (42), (21), (18), (13), (10), (7), (4), (2), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (3), (2), (2), (2), (1), (1), (1), (1)
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