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Brain Expressed, X-Linked 1 (BEX1) (AA 15-60) antibody

Details for Product No. ABIN350122, Supplier: Login to see
Antigen
  • BEX1
  • AA407839
  • AU018692
  • Bex4
  • Rex3
  • BEX2
  • HBEX2
  • HGR74-h
Alternatives
anti-Human Brain Expressed, X-Linked 1 antibody for Western Blotting
Epitope
AA 15-60
16
13
10
2
1
1
1
1
1
1
Reactivity
Human
26
6
3
Host
Rabbit
27
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
24
18
16
16
4
2
1
Supplier
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Immunogen A synthetic peptide from aa region 15-60 of human BEX1 conjugated to blue carrier protein was used as the antigen.
Specificity Specific for BEX1 (BEX2).
Purification Whole serum
Alternative Name BEX1 (BEX1 Antibody Abstract)
Background Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
Subunit: Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP.
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus.
Tissue specificity: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. Also known as: BEX1, BEX2, HBEX2, HGR74-h.
Pathways Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 200 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Quentmeier, Tonelli, Geffers et al.: "Expression of BEX1 in acute myeloid leukemia with MLL rearrangements." in: Leukemia, Vol. 19, Issue 8, pp. 1488-9, 2005 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Yang, Xia, Gu et al.: "Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22." in: Biochemical genetics, Vol. 40, Issue 1-2, pp. 1-12, 2002 (PubMed).