Brain Expressed X-Linked 2 (BEX2) antibody

Antigen: Brain Expressed X-Linked 2 (BEX2)

Synonyms: BEX1, DJ79P11.1

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350122

Additional Information

Alternative name: Brain-expressed X-linked protein 1 (BEX1, also called BEX2)

Swiss-Prot: Q9HBH7

Immunogen: A synthetic peptide as a part of human Brain-expressed X-linked protein 1 (BEX1, also called BEX2, HBEX2, HGR74-h) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. SUBUNIT: Interacts with neurotrophin receptor p75NTR/NGFR. <||a href="http://www.osenses.com/olfactory-marker-protein-c-21_87.html">Interacts with OMP.<||/a> SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. TISSUE SPECIFICITY: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. Also known as: BEX1, BEX2, HBEX2, HGR74-h.

Specificity: Appears to be specific for BEX1 (BEX2).

Application Details

Application Notes: IHC, WB. A dilution of 1 : 200 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Yang, Xia, Gu et al.: "Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22." in: Biochemical genetics, Vol. 40, Issue 1-2, pp. 1-12, 2002 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Quentmeier, Tonelli, Geffers et al.: "Expression of BEX1 in acute myeloid leukemia with MLL rearrangements." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 19, Issue 8, pp. 1488-9, 2005 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).