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Brain Expressed, X-Linked 1 (BEX1) (AA 2-40) antibody

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Synonyms BEX1, AA407839, AU018692, Bex4, Rex3, BEX2, HBEX2, HGR74-h
AA 2-40
(16), (13), (10), (2), (1), (1), (1), (1), (1), (1)
Rat (Rattus), Mouse (Murine)
(27), (5), (2)
(27), (1)
(2), (2), (2), (2), (2), (2), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(24), (18), (16), (16), (4), (2), (1)
Pubmed 3 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 2-40 of mouse BEX1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.
Specificity Specific for BEX1 and BEX2.
Purification Whole serum
Alternative Name BEX1 (BEX1 Antibody Abstract)
Background BEX1:
Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
Subunit: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR.
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
Tissue specificity: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.
Developmental stage: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level). BEX2:
Subunit: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP.
Subcellular location: Nucleus. Cytoplasm. Also known as: Brain expressed gene 1, BEX1, EG2RVC, BEX2,Brain-expressed X-linked protein 2 homolog.
Pathways Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Vilar, Murillo-Carretero, Mira et al.: "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." in: The EMBO journal, Vol. 25, Issue 6, pp. 1219-30, 2006 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Feng, Liang, Wong-Riley: "Differential gene expressions in the visual cortex of postnatal day 1 versus day 21 rats revealed by suppression subtractive hybridization." in: Gene, Vol. 329, pp. 93-101, 2004 (PubMed).

Catalog No. ABIN350123
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