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Details for Product No. ABIN350123

Brain Expressed, X-Linked 1/2 (BEX1/BEX2) (N-Term) antibody

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Synonyms BEX1
Rat (Rattus), Mouse (Murine)
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350123
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide as a part of rat, mouse Brain-expressed X-linked protein 1 and 2 (BEX1, BEX2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for BEX1 and BEX2.
Purity whole serum
Alternative Name Brain-expressed X-linked protein 1 and 2 (BEX1, BEX2)
Background BEX1:
Function: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
Subunit: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR.
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
Tissue specificity: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.
Developmental stage: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level). BEX2:
Subunit: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP.
Subcellular location: Nucleus. Cytoplasm. Also known as: Brain expressed gene 1, BEX1, EG2RVC, BEX2,Brain-expressed X-linked protein 2 homolog.
UniProt Q3MKQ2
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Feng, Liang, Wong-Riley: "Differential gene expressions in the visual cortex of postnatal day 1 versus day 21 rats revealed by suppression subtractive hybridization." in: Gene, Vol. 329, pp. 93-101, 2004 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Vilar, Murillo-Carretero, Mira et al.: "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." in: The EMBO journal, Vol. 25, Issue 6, pp. 1219-30, 2006 (PubMed).