Brain Expressed X-Linked 2 (BEX2) (N-Term) antibody

Antigen: Brain Expressed X-Linked 2 (BEX2)

Synonyms: BEX1, DJ79P11.1

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350123

Additional Information

Alternative name: Brain-expressed X-linked protein 1 and 2 (BEX1, BEX2) (n-terminal region)

Swiss-Prot: Q3MKQ2

Immunogen: A synthetic peptide as a part of rat, mouse Brain-expressed X-linked protein 1 and 2 (BEX1, BEX2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: BEX1: FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. SUBUNIT: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. TISSUE SPECIFICITY: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve. DEVELOPMENTAL STAGE: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level). BEX2: SUBUNIT: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Also known as: Brain expressed gene 1, BEX1, EG2RVC; BEX2,Brain-expressed X-linked protein 2 homolog.

Specificity: Appears to be specific for BEX1 and BEX2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Feng, Liang, Wong-Riley: "Differential gene expressions in the visual cortex of postnatal day 1 versus day 21 rats revealed by suppression subtractive hybridization." in: Gene, Vol. 329, pp. 93-101, 2004 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Vilar, Murillo-Carretero, Mira et al.: "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle." in: The EMBO journal, Vol. 25, Issue 6, pp. 1219-30, 2006 (PubMed).