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Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) antibody

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Synonyms NGFRAP1, BEX3, Bex, DXS6984E, HGR74, NADE, AL033356, Bex3, DXWsu67e, Gcap27, Nade, WBP5
(75), (32), (22), (1), (1)
(57), (15), (6)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(50), (41), (11), (11), (11), (5), (2), (1)
Pubmed 4 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for BEX3.
Purification Whole serum
Alternative Name BEX3 (NGFRAP1 Antibody Abstract)
Background Function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases.
Subunit: Self-associates. Interacts with 14-3-3 epsilon. Interacts with DIABLO/SMAC. Binds to the DEATH domain of p75NTR/NGFR.
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. Also known as: Protein BEX3, NGFRAP1, p75NTR-associated cell death executor, Nerve growth factor receptor-associated protein 1 (TNFRSF16) associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, BEX3, DXS6984E, NADE, Bex, HGR74, DXS6984E.
Pathways Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome. ..." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Mukai, Hachiya, Shoji-Hoshino et al.: "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17566-70, 2000 (PubMed).

Rapp, Freudenstein, Klaudiny et al.: "Characterization of three abundant mRNAs from human ovarian granulosa cells." in: DNA and cell biology, Vol. 9, Issue 7, pp. 479-85, 1990 (PubMed).

Catalog No. ABIN350124
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