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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) antibody
|Synonyms||Bex, BEX3, NADE, HGR74, DXS6984E, NGFRAP1|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE)|
|Immunogen||A synthetic peptide from human Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE) conjugated to an immunogenic carrier protein was used as the immunogen.|
|Description||FUNCTION: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. SUBUNIT: Self-associates. Interacts with 14-3-3 epsilon. Interacts with DIABLO/SMAC. Binds to the DEATH domain of p75NTR/NGFR. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. TISSUE SPECIFICITY: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. Also known as: Protein BEX3, NGFRAP1, p75NTR-associated cell death executor, Nerve growth factor receptor-associated protein 1 (TNFRSF16) associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, BEX3, DXS6984E, NADE, Bex, HGR74, DXS6984E.|
|Specificity||Appears to be specific for BEX3.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Rapp, Freudenstein, Klaudiny et al.: "Characterization of three abundant mRNAs from human ovarian granulosa cells." in: DNA and cell biology, Vol. 9, Issue 7, pp. 479-85, 1990 (PubMed).
Mukai, Hachiya, Shoji-Hoshino et al.: "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17566-70, 2000 (PubMed).
Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).
Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).
|Hosts||Rabbit (33), Goat (3), Mouse (1)|
|Reactivities||Human (33), Mouse (Murine) (26), Rat (Rattus) (21), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (20), Immunofluorescence (IF) (15), ELISA (13), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (IHC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (1), Internal Region (1), Middle Region (1), N-Term (1)|