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Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (N-Term) antibody

Details for Product No. ABIN350125, Supplier: Log in to see
Antigen
  • NGFRAP1
  • BEX3
  • Bex
  • DXS6984E
  • HGR74
  • NADE
  • AL033356
  • Bex3
  • DXWsu67e
  • Gcap27
  • Nade
  • WBP5
  • nerve growth factor receptor (TNFRSF16) associated protein 1
  • NGFRAP1
  • LOC100349701
  • Ngfrap1
Alternatives
anti-Mouse (Murine) Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 antibody for Western Blotting
Epitope
N-Term
14
12
10
4
4
3
2
2
2
2
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine)
77
34
24
2
2
1
1
1
1
1
Host
Rabbit
58
15
6
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
51
41
13
12
10
6
2
1
1
Options
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Immunogen A synthetic peptide from n-terminal region of mouse BEX3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.
Specificity Specific for BEX3.
Purification Whole serum
Alternative Name BEX3 (NGFRAP1 Antibody Abstract)
Background Function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. Binds transition metals. This protein is probably ubiquitinated and is degraded by the proteasome.
Subunit: Self-associates. Binds to the DEATH domain of p75NTR/NGFR. Interacts with 14-3-3 epsilon. Interacts with DIABLO/SMAC.
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
Tissue specificity: widely expressed. In cochlea, it is expressed in pillar cells from postnatal day 2 to adulthood. Also known as: Protein BEX3, NGFRAP1, p75NTR-associated cell death executor, Nerve growth factor receptor-associated protein 1 (TNFRSF16) associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, BEX3, NADE.
Pathways Neurotrophin Signaling Pathway
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Alvarez, Zhou, Witta, Freed: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).

Yi, Lee, Sato, Koh: "Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat." in: Neuroscience letters, Vol. 347, Issue 2, pp. 126-30, 2003 (PubMed).

Park, Lee, Sato, Koh: "Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 24, pp. 9096-103, 2001 (PubMed).

Sano, Mukai, Monoo, Close, Sato: "Expression of p75NTR and its associated protein NADE in the rat cochlea." in: The Laryngoscope, Vol. 111, Issue 3, pp. 535-8, 2001 (PubMed).

Mukai, Hachiya, Shoji-Hoshino, Kimura, Nadano, Suvanto, Hanaoka, Li, Irie, Greene, Sato: "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17566-70, 2000 (PubMed).