Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (N-Term) antibody

Antigen: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Synonyms: Bex, BEX3, NADE, HGR74, DXS6984E, NGFRAP1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350125

Additional Information

Alternative name: Brain-expressed X-linked protein 3 (BEX3)

UniProt: Q6PDU5

Immunogen: A synthetic peptide as a part of rat, mouse Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. Binds transition metals. This protein is probably ubiquitinated and is degraded by the proteasome. SUBUNIT: Self-associates. Binds to the DEATH domain of p75NTR/NGFR. Interacts with 14-3-3 epsilon. Interacts with DIABLO/SMAC. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. TISSUE SPECIFICITY: widely expressed. In cochlea, it is expressed in pillar cells from postnatal day 2 to adulthood. Also known as: Protein BEX3, NGFRAP1, p75NTR-associated cell death executor, Nerve growth factor receptor-associated protein 1 (TNFRSF16) associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, BEX3, NADE.

Specificity: Appears to be specific for BEX3.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Mukai, Hachiya, Shoji-Hoshino et al.: "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17566-70, 2000 (PubMed).

Park, Lee, Sato et al.: "Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 24, pp. 9096-103, 2001 (PubMed).

Sano, Mukai, Monoo et al.: "Expression of p75NTR and its associated protein NADE in the rat cochlea." in: The Laryngoscope, Vol. 111, Issue 3, pp. 535-8, 2001 (PubMed).

Yi, Lee, Sato et al.: "Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat." in: Neuroscience letters, Vol. 347, Issue 2, pp. 126-30, 2003 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).