Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) (AA 1000-1050) antibody

Details for Product No. ABIN350134
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BccA1, rbA-1, Cav2.1, APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6, la, tg, rkr, Caca1a, Ccha1a, leaner, nmf352, rocker, alpha1A, Cacnl1a4, tottering, CACH4, CACN3, cav2.1, cacna-a, ca( ... show more
BccA1, rbA-1, Cav2.1, APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6, la, tg, rkr, Caca1a, Ccha1a, leaner, nmf352, rocker, alpha1A, Cacnl1a4, tottering, CACH4, CACN3, cav2.1, cacna-a, ca(v)2.1, cacna1a, si:ch211-237k17.1 show less
AA 1000-1050
(3), (3), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus), Human
(24), (18), (17), (12), (12)
(23), (1)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(11), (10), (6), (3), (3), (1)
Pubmed 5 references available
Catalog no. ABIN350134
Quantity 100 µL
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Immunogen A synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen. The antigen shares 87% identity with mouse and rat sequence.
Specificity Specific for KCNS2.
Purification whole serum
Alternative Name CACNA1A (Cav2.1)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Brain specific, mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also known as: BI, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel L type alpha-1 polypeptide, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1.
UniProt O35219
Research Area Cardiovascular
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Barry, Viglione, Kim et al.: "Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 1, pp. 274-83, 1995 (PubMed).

Ophoff, Terwindt, Vergouwe et al.: "Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4." in: Cell, Vol. 87, Issue 3, pp. 543-52, 1996 (PubMed).

Hans, Urrutia, Deal et al.: "Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels." in: Biophysical journal, Vol. 76, Issue 3, pp. 1384-400, 1999 (PubMed).

Ducros, Denier, Joutel et al.: "The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel." in: The New England journal of medicine, Vol. 345, Issue 1, pp. 17-24, 2001 (PubMed).

Mantuano, Veneziano, Spadaro et al.: "Clusters of non-truncating mutations of P/Q type Ca2+ channel subunit Ca(v)2.1 causing episodic ataxia 2." in: Journal of medical genetics, Vol. 41, Issue 6, pp. e82, 2004 (PubMed).

Hosts (23), (1)
Reactivities (24), (18), (17), (12), (12)
Applications (11), (10), (6), (3), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (1), (1), (1), (1)
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