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CACNA1A antibody (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit) (AA 1000-1050)

Details for Product anti-CACNA1A Antibody No. ABIN350134, Supplier: Log in to see
Antigen
  • alpha1A
  • APCA
  • BccA1
  • BI
  • ca(v)2.1
  • Caca1a
  • CACH4
  • CACN3
  • cacna-a
  • cacna1a
  • Cacnl1a4
  • CACNL1A4
  • Cav2.1
  • CAV2.1
  • cav2.1
  • Ccha1a
  • EA2
  • FHM
  • HPCA
  • la
  • leaner
  • MHP
  • MHP1
  • nmf352
  • rbA-1
  • rkr
  • rocker
  • SCA6
  • si:ch211-237k17.1
  • tg
  • tottering
Epitope
AA 1000-1050
4
4
2
2
1
1
1
Reactivity
Human
27
21
20
Host
Rabbit
28
1
Clonality
Polyclonal
Conjugate
This CACNA1A antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
13
11
9
4
2
1
Supplier
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Supplier Product No.
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Immunogen A synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen. The antigen shares 87% identity with mouse and rat sequence.
Specificity Specific for CACNA1A.
Purification Whole serum
Alternative Name CACNA1A (CACNA1A Antibody Abstract)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Brain specific, mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also known as: BI, Brain calcium channel I, Cach4, Cacn3, Cacna1a, Cacnl1a4, Calcium channel L type alpha-1 polypeptide, Voltage-dependent P/Q-type calcium channel alpha-1A subunit, Voltage-gated calcium channel alpha subunit Cav2.1.
Research Area Cancer
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Mantuano, Veneziano, Spadaro, Giunti, Guida, Leggio, Verriello, Wood, Jodice, Frontali: "Clusters of non-truncating mutations of P/Q type Ca2+ channel subunit Ca(v)2.1 causing episodic ataxia 2." in: Journal of medical genetics, Vol. 41, Issue 6, pp. e82, 2004 (PubMed).

Ducros, Denier, Joutel, Cecillon, Lescoat, Vahedi, Darcel, Vicaut, Bousser, Tournier-Lasserve: "The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel." in: The New England journal of medicine, Vol. 345, Issue 1, pp. 17-24, 2001 (PubMed).

Hans, Urrutia, Deal, Brust, Stauderman, Ellis, Harpold, Johnson, Williams: "Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels." in: Biophysical journal, Vol. 76, Issue 3, pp. 1384-400, 1999 (PubMed).

Ophoff, Terwindt, Vergouwe, van Eijk, Oefner, Hoffman, Lamerdin, Mohrenweiser, Bulman, Ferrari, Haan, Lindhout, van Ommen, Hofker, Ferrari, Frants: "Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4." in: Cell, Vol. 87, Issue 3, pp. 543-52, 1996 (PubMed).

Barry, Viglione, Kim, Froehner: "Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 15, Issue 1 Pt 1, pp. 274-83, 1995 (PubMed).