Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) (Cytoplasmic Domain) antibody

Details for Product No. ABIN350135
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Antigen
Synonyms BIII, CACNL1A5, CACNN, Cav2.2, AW050276, AW060892, AW822256, Cchn1a, alpha(1B)
Epitope
Cytoplasmic Domain
(3), (3), (3), (2), (2), (1), (1)
Reactivity
Human
(17), (8), (7)
Host
Rabbit
(20)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(19), (9), (6), (5), (2), (1)
Pubmed 4 references available
Quantity 100 µL
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Catalog No. ABIN350135
454.67 $
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Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1B (Cav2.2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 85% identity with mouse and rat sequence.
Specificity Specific for CACNA1B.
Purification Whole serum
Alternative Name CACNA1B
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Also known as: CACNL1A5, CACNN, calcium channel N type, Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-gated calcium channel subunit alpha Cav2.2, CACNL1A5, Calcium channel, L type, alpha-1 polypeptide isoform 5.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Williams, Brust, Feldman et al.: "Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel." in: Science (New York, N.Y.), Vol. 257, Issue 5068, pp. 389-95, 1992 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).

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