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Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) (Cytoplasmic Domain) antibody
|Synonyms||BIII, CACNN, Cav2.2, CACNL1A5, Cchn1a, AW050276, AW060892, AW822256, alpha(1B), CACNA1B|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|4 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||CACNA1B (Cav2.2)|
|Immunogen||A synthetic peptide from a cytoplasmic domain of human CACNA1B (Cav2.2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 85% identity with mouse and rat sequence.|
|Description||FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Also known as: CACNL1A5, CACNN, calcium channel N type, Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-gated calcium channel subunit alpha Cav2.2, CACNL1A5, Calcium channel, L type, alpha-1 polypeptide isoform 5.|
|Specificity||Appears to be specific for CACNA1B.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Williams, Brust, Feldman et al.: "Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel." in: Science (New York, N.Y.), Vol. 257, Issue 5068, pp. 389-95, 1992 (PubMed).
Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).
|Reactivities||Human (15), Mouse (Murine) (7), Rat (Rattus) (7), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (16), ELISA (8), Immunohistochemistry (IHC) (8), Immunofluorescence (IF) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunoprecipitation (IP) (1)|
|Epitopes||C-Term (2), N-Term (2)|