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Details for Product No. ABIN350135

Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) (Cytoplasmic Domain) antibody

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Antigen
Synonyms BIII, CACNN, Cav2.2, CACNL1A5, Cchn1a, AW050276, AW060892, AW822256, alpha(1B)
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350135
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1B (Cav2.2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 85% identity with mouse and rat sequence.
Specificity Specific for KCNJ1.
Purity whole serum
Alternative Name CACNA1B (Cav2.2)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Also known as: CACNL1A5, CACNN, calcium channel N type, Voltage-dependent N-type calcium channel subunit alpha-1B, Voltage-gated calcium channel subunit alpha Cav2.2, CACNL1A5, Calcium channel, L type, alpha-1 polypeptide isoform 5.
UniProt O88335
Research Area Signaling, Metabolism
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Williams, Brust, Feldman et al.: "Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel." in: Science (New York, N.Y.), Vol. 257, Issue 5068, pp. 389-95, 1992 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Imami, Sugiyama, Kyono et al.: "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Vol. 24, Issue 1, pp. 161-6, 2008 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B)", type "Antibodies"
Hosts (20)
Reactivities (17), (8), (7)
Applications (19), (9), (6), (4), (2)
Epitopes (3), (3), (3), (2), (1), (1)
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