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Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C) (AA 50-100) antibody

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Synonyms isl, C-LTCC, ICA, cav1.2, ca(v)1.2, CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, Cav1.2, Cchl1a1, MBC, MELC-CC, RATIVS302, CAV1.2, CHCACHA1C, CACH2C, Cacna1c
AA 50-100
(58), (35), (20), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Rat (Rattus), Mouse (Murine)
(91), (41), (35), (21), (20), (6), (5), (5), (4), (4), (4), (1)
(78), (60), (17)
(13), (8), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(86), (60), (40), (34), (24), (19), (12), (11), (4), (3), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from aa region 50-100 of human CACNA1C conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence.
Specificity Specific for CACNA1C.
Purification Whole serum
Alternative Name CACNA1C (CACNA1C Antibody Abstract)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. Also known as: CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Antzelevitch, Pollevick, Cordeiro et al.: "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death." in: Circulation, Vol. 115, Issue 4, pp. 442-9, 2007 (PubMed).

Scherer, Muzny, Buhay et al.: "The finished DNA sequence of human chromosome 12. ..." in: Nature, Vol. 440, Issue 7082, pp. 346-51, 2006 (PubMed).

Zuehlke, Bouron, Soldatov et al.: "Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene." in: FEBS letters, Vol. 427, Issue 2, pp. 220-4, 1998 (PubMed).

Schultz, Mikala, Yatani et al.: "Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 6228-32, 1993 (PubMed).

Soldatov, Bouron, Reuter: "Different voltage-dependent inhibition by dihydropyridines of human Ca2+ channel splice variants." in: The Journal of biological chemistry, Vol. 270, Issue 18, pp. 10540-3, 1995 (PubMed).

Catalog No. ABIN350136
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